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Impaired Methylation in Pregnancy

During pregnancy, the body undergoes tremendous changes and is under significant stress. Keeping all the body systems working properly can help ensure the health of both mother and baby. One bodily process that is essential as the baby grows in the womb is called methylation. Methylation is necessary for the proper formation and function of cells, cell membranes, and nerves. During pregnancy, the need for methylation increases dramatically. When methylation is not happening as it should during pregnancy, it can result in miscarriage, pregnancy complications, or birth defects. Contributing Factors Because methylation is happening at such a fast rate during […]

Prenatal Omega-3 Supplementation and Epigenetics of Infant Immunity

Does prenatal omega-3 intake influence epigenetics in the infant’s immune system? Results of a controlled trial show no epigenetic effect of docosahexaenoic acid supplementation in infants of nonsmoking mothers but an increase in global DNA methylation in infants of smoking mothers. Reference Lee HS, Barraza-Villarreal A, Hernandez-Vargas H, et al. Modulation of DNA methylation states and infant immune system by dietary supplementation with omega-3 PUFA during pregnancy in an intervention study. Am J Clin Nutr. 2013;98(2):480-487. Overview The aim of this study was to determine whether maternal supplementation with docosahexaenoic acid (DHA) during pregnancy would create epigenetic changes in the […]

Folic Acid Supplementation and Intracellular 1-Carbon Metabolism

How does folic acid supplementation affect intracellular 1-carbon metabolism? A randomized controlled trial shows folic acid supplementation does not decrease intracellular homocysteine and may disrupt normal regulation of intracellular 1-carbon metabolism. Reference Smith DE, Hornstra JM, Kok RM, Blom HJ, Smulders YM. Folic acid supplementation does not reduce intracellular homocysteine, and may disturb intracellular one-carbon metabolism. Clin Chem Lab Med. 2013;51(8):1643-1650. Overview The purpose of this study was to examine the effect of folic acid supplementation on intracellular concentrations of 1-carbon (1C) metabolites, including homocysteine, s-adenosylmethionine (SAM), and s-adenosylhomocysteine (SAH). Study Design Double-blind randomized placebo-controlled trial. Results Fifty healthy volunteers […]

Omega-3−Enriched Eggs and Choline Metabolism in Women

Does egg consumption alter choline metabolism in vegetarian women? In vegetarian women, consumption of eggs, especially omega-3−enriched eggs, increased serum free choline and betaine when compared to controls.  Reference West AA, Shih Y, Wang W, et al. Egg n-3 Fatty Acid Composition Modulates Biomarkers of Choline Metabolism in Free-Living Lacto-Ovo-Vegetarian Women of Reproductive Age. J Acad Nutr Diet. 2014;114(10):1594-1600. Overview This study was designed to determine how omega-3−enriched eggs and nonenriched eggs influence biomarkers of choline metabolism in vegetarian women of reproductive age. Study Design Randomized crossover study. Results Fifteen premenopausal women were assigned to three 8-week dietary treatments separated […]

Maternal Choline Intake and the Epigenetics of Cortisol-Regulating Genes

Does prenatal choline intake affect the expression of cortisol-regulating genes? A controlled trial demonstrates that higher prenatal choline intake during the third trimester of pregnancy may counter some of the adverse effects of prenatal stress on behavioral, neuroendocrine and metabolic development in the fetus. Reference Jiang X, Yan J, West AA, et al. Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans. FASEB J. 2012;26(8):3563-3574. Overview This study was designed to assess the effect of maternal choline intake on the epigenetic state of cortisol-regulating genes. Study Design Randomized controlled trial. Results Placental samples were collected from […]

Arsenic Toxicity and Methylation in Pregnancy

A huge misconception about methylation defects is that they are only caused by genetic single-nucleotide polymorphisms (SNPs). This could not be further from the truth. Nutrient deficiencies, pathogens, stress, and environmental toxins can all disrupt methylation. One of these toxins—one that is ubiquitous but often overlooked—is arsenic. Arsenic is a heavy metal. The inorganic form of arsenic is a known carcinogen, linked to bladder, lung, and skin cancers.i The metabolism and elimination of inorganic arsenic from the body requires glutathione, our primary detoxification agent, and s-adenosylmethionine (SAM), our primary methyl donor. In addition, arsenic blocks ATP production at the cellular […]

Prenatal Stress and Methylation

Pregnancy is a physically demanding time, requiring more nutrients, calories, water, and rest. It is also an emotionally demanding time, marked by anticipation and sometimes worry or anxiety. If a woman’s physical or emotional needs are not met, her body will respond with a physiological stress response. This response is mediated by catecholamines (e.g. epinephrine and norepinephrine), neurotransmitters (e.g. serotonin), and cortisol. Catecholamines decrease placental blood flow; serotonin affects infant brain development; elevated cortisol increases the risk of miscarriage; and maternal cortisol may influence birth weight, cognitive development, and infant temperament.i,ii,iii,iv It is clear that stress can play a role […]

Folic Acid in Pregnancy: A Case Study

A couple came to see me after experiencing spontaneous abortion of a fetus with anencephaly. Anencephaly is a severe midline defect in which the brain does not form; it is the most extreme form of neural tube defects. Genetic testing revealed that both the man and the woman had a single-nucleotide polymorphism (SNP) in the methylenetetrahydrofolate reductase (MTHFR) gene. This means that their capacities to generate the active form of folate were significantly compromised, putting their pregnancy at risk for birth defects and miscarriage.i Their physician had prescribed 4 mg of folic acid daily. I disagreed with this recommendation, for […]

Prenatal Methylation Assessment and Dysfunction – A discussion between TAP and Dr. Ben Lynch

Methylation is defined as the addition of 1 carbon and 3 hydrogen atoms to a compound. This biochemical reaction influences innumerable functions in the body, including genetic expression, neurotransmitter synthesis, and detoxification. During pregnancy, with the increased production of maternal hormones and rapid multiplication of cells in the developing baby, the demand for methylation increases dramatically. Impaired methylation during pregnancy can result in spontaneous abortion, pregnancy complications, or birth defects. Ben Lynch, ND has a unique perspective on methylation during pregnancy. Not only does he emphasize the importance of methylation assessment during prenatal screenings, but also emphasizes the need to […]

Earn Revenue by Raising Awareness – SHEI Affiliate Program

As it has for many around the world, has your life improved with information presented by Dr Lynch? Have you told friends, colleagues and family about StrateGene, Memberships or online courses such as Part 1 and 2? We want to thank you by offering a commission to any sales generated by you! Raise awareness, and earn commissions, by becoming a SHEI Affiliate! With the SHEI affiliate program you will earn a generous 30% commission on sales closed within 60 days! We also have pre-made marketing materials for you to use – such as: Banners               […]

FB Live StrateGene Q&A Transcript: Sept. 1st

Facebook Live Event Q&A with Dr Lynch 0:04:42 Q: What is the best test to measure mineral levels? A: The best test to order to evaluate mineral levels. That’s tough. I will say there are a number of tests out there. What we are trying to do is we’re trying not to be biased on one lab company or another. I will mention a few. There’s organic acids. Organic acid tests can show a number of things, so urinary organic acids. Intracellular nutrient testing is also very useful. Red blood cell RBC nutrient levels, mineral levels are also useful, RBC […]

FB Live StrateGene Q&A Transcript: August 23rd

StrateGene Facebook Live Part 3 Q&A with Dr Lynch 0:02:48 Q: Do Sprout People have stainless or glass to grow? A: Good question. I wanted the same thing. Sprout People, we talked about them last time. Look at the Facebook Live video from previous where we talked about Sprout People. SproutPeople.com, do they have a stainless steel or glass container to grow sprouts in? Not that I’m aware of. No. You can create your own and develop a new product. That would be a phenomenal idea. They do use a safer plastic. You know plastic is not idea, right? I […]

FB Live StrateGene Q&A Transcript: August 19th

StrateGene Facebook Live Part 2 Q&A with Dr Lynch 0:06:23 Q: May I ask about the MAOA gene? MAOT941G with the -/-, T. The variant is associated with normal/wild type MAOA slower activity compared to GG or GT. Does this mean is wild because it only has a T? How do I determine the up and down regulations? A: Great question. This is where a lot of confusion comes into play. Let me put this down for a second. On our reporting tool, we highlight the genes as green for ancestral allele meaning that is what’s found commonly among the […]

FB Live StrateGene Q&A Transcript: August 18th

StrateGene Facebook Live Part 1 Q&A with Dr Lynch   0:03:54 Q: I was hoping to ask about the DMGDH and whether multiple homozygous SNPs are clinically relevant at all, or can I assume that they aren’t since they aren’t included. A: DMGDH enzyme, multiple homozygous variants that they see in 23andMe or these other reporting tools that they used in the past. They’re not seeing that reported on StrateGene. Does that automatically mean that it’s not clinically relevant and there’s no action to be taken? No, that does not mean that. It’s a good insight. What I did is […]

Wake-up your natural alarm clock!

You don’t have to lose sleep about not being able to wake-up in the morning… Nor do you have to rely on artificial stimulants to wake-up.     Sometimes your adrenals just need a little TLC or your room needs more light in the morning to shut down melatonin production. A few simple changes may just help you find your get-up-and-go in the morning! Trouble waking up in the morning? Become a morning person with a few simple tips! #adrenals #melatonin @drbenlynch   Full Transcript: “Oh, shut up. It’s not time to get up yet. Can’t wake up. Leave me alone. […]

I Can’t Fall Asleep

Turn, turn, turn…   Okay this isn’t a reference to the Byrds’ song, but your sleeping habits, or lack thereof!   You can pull the covers over your sleepless nights by identifying some common triggers such as: Eating high histamine containing foods Eating high glutamate containing foods Having even a small amount of light in the bedroom Watch the video below, for the full scoop on what you can do to get your z’s – besides counting sheep! #Histamine, #Glutamate & #Neurotransmitters – triggers to your sleepless nights? #sleep. Full Transcript: “Man, will you stop moving around? Every night you’re […]

Can’t Stay Asleep?

  Feeding schedules aren’t just for babies…       In fact one of the reasons that many people can’t sleep through the night is due to low blood sugar. This is usually the result of eating dinner too early or eating an imbalanced meal. Watch the video below for tips on how you can start sleeping like a baby…   #Sleep through the night by adjusting what you eat & when you eat. #healthtips Full Transcript: Hey, Dr. Ben Lynch here. So maybe you saw the Can’t Fall Asleep video. Maybe that works for you. But now you can’t […]

SHEICON2016 Q&A Webinar

Want a taste of SHEICON2016? Get an overview of what the conference was all about as Dr. Lynch addresses some of the attendee submitted questions.

Master Class with Dr. Ben Lynch, ND – Starting an Online Business and Creating an Online Presence

“Follow your passions, do what you love, and don’t let anything get in your way. You’ve all got it. We don’t compete with each other. We support each other.” When I was in medical school, I knew that Dr. Lynch was different…in a good way. He used an email opt-in form on his website to stay connected with readers, which showed me he had marketing savvy. He put on sold out conferences at Bastyr University, which showed me that he knew things that others wanted to learn. Most importantly, he showed me what it means to have the courage to speak […]

Dr. Lynch’s interview with Dr. Ritamarie

http://s3.amazonaws.com/drritamarie/videos/INE/INE-ACR-GuestFacultyResources-DrBenLynch-HighEstrogen-HaveYouCheckedMethylationStatus-Video.mp4 Audio http://drritamarie.s3.amazonaws.com/audio/INE/INE-ACR-GuestFacultyResources-DrBenLynch-HighEstrogen-HaveYouCheckedMethylationStatus-Audio.mp3 Download Full Slides Download Printer-Friendly Slides Download Transcript PDF

Case Study Webinar with Bernarda Zenker

Interested in learning more about why patients may be expressing certain symptoms? In this webinar, Dr. Bernarda Zenker extrapolates a case study on a 27 year old female with chronic migraines and tension headaches, insomnia and environmental allergies.

Case Study Webinar with Dr. Jess Armine – Methylation, Anxiety, Inflammation…What’s the connection?

Ready to see the Pathway Planner in action? Dr. Jess Armine shares a case study on the connection between methylation, anxiety, and inflammation. Both Dr. Lynch and Dr. Armine also address questions related to the case study.

How to Sauna Clinical Webinar

Wondering if sauna therapy would be beneficial for you or your patients? In this webinar, Dr. Lynch addresses questions on ‘how to sauna’ for maximum health benefits.

TAP Integrative Review – Evidence Based Continuing Education for Busy Doctors

TAP Integrative combines top experts and the latest evidence and distills the clinical pearls into convenient bite-sized pieces. TAP Integrative is a non-profit organization started by Dr. Lise Alschuler, ND, FABNO, a respected author, educator and presenter with the support of Integrative Therapeutics. You can tell that Dr. Alschuler and her team put a lot of thought into the clinical topics and the layout of the site. Let’s take a tour. Clinical Topics Every month, there is a new Clinical Topic featuring an interview with an expert. Here’s a screenshot of our very own Dr. Lynch featured in the Clinical Topic, “Methylation […]

Arginine Webinar

Arginine metabolism questions? In this webinar, Dr. Lynch addresses questions from SHEICON attendees on the Pathway Planner. As one attendee commented, “I like this approach of focusing on a specific pathway for each webinar.” Key takeaways according to attendees –  The effect of Arginine metabolism on Polyamines Ammonia component of the arginine cycle.  Utilize creatinine more often in order to conserve arginine. Arginine/Lysine ratio and its role in  dehydration, weight loss  and  loss of muscle mass.

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