Linking The Methylation Cycle with Detoxification
•The epidemic of epidemics of cardiovascular, immunological and neurological diseases is likely associated with environmental toxicants.
• Metal and chemical toxicants compete for key endogenous detoxification processes.
• Methionine has a central role in detoxification and, methionine metabolism can be disrupted by toxicants, oxidative stress, nutritional insufficiencies and single nucleotide polymorphisms.
• Definitive laboratory tests are available to help clinicians identify bottlenecks in detoxification processes and formulate specific treatment protocols for individual patients.
Key Clinical Takeaways
• Describe the primary endogenous detoxification processes and recognize where toxicants and nutritional insufficiencies impede the processes.
• Explain the three primary pathways of methionine metabolism as related to detoxification and health.
• Summarize genetic and epigenetic factors that can disrupt methionine metabolism, including methylation and transsulfuration.
• Employ appropriate laboratory testing to assess (1) exposure to toxicants, (2) ability to detoxify, (3) status of obligatory nutrient co-factors for detoxification and, (4) phenotypic expression of genes involved in methionine metabolism.